MT-802
MT-802 is a potent PROTAC that induces Bruton’s tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
Trivial name | N/A |
Catalog Number | S6966 |
Molecular Formula | C41H41N9O8 |
CAS# | 2231744-29-7 |
SMILES | NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCN(CCOCCOCC(=O)NC6=CC7=C(C=C6)C(=O)N(C8CCC(=O)NC8=O)C7=O)CC5 |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/mt-802.html |
Additional Information | https://file.selleck.cn/downloads/struct/s6966-mt-802-chemical-structure.gif |