FM-381
FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.
| Trivial name | N/A |
| Catalog Number | S8541 |
| Molecular Formula | C24H24N6O2 |
| CAS# | 2226521-65-7 |
| Inchi | InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+ |
| Inchi Key | GJMZWYLOARVASY-NTCAYCPXSA-N |
| SMILES | CN(C)C(=O)C(=CC1=CC=C(O1)C2=NC3=CN=C4C(=C3N2C5CCCCC5)C=CN4)C#N |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/fm-381.html |
| Additional Information | https://file.selleck.cn/downloads/struct/fm-381-chemical-structure-s8541.gif |