PD173074
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.
| Trivial name | N/A |
| Catalog Number | S1264 |
| Molecular Formula | C12H19NO2 |
| CAS# | 219580-11-7 |
| Inchi | InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1 |
| Inchi Key | FTBQORVNHOIASH-CKYFFXLPSA-N |
| SMILES | CCC1=CC2C(C1)CC2(CC(=O)O)CN |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/PD-173074.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PD173074-chemical-structure-s1264.gif |