PD173074

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.

Price Not Available 10mM/1mL PD173074 Supplier Page
Trivial name N/A
Catalog Number S1264
Molecular Formula C28H41N7O3
CAS# 219580-11-7
Inchi InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
Inchi Key DXCUKNQANPLTEJ-UHFFFAOYSA-N
SMILES CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
Size 10mM/1mL
Supplier Page http://www.selleckchem.com/products/PD-173074.html
Additional Information https://file.selleck.cn/downloads/struct/PD173074-chemical-structure-s1264.gif