PD173074
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.
| Trivial name | N/A |
| Catalog Number | S1264 |
| Molecular Formula | C28H41N7O3 |
| CAS# | 219580-11-7 |
| Inchi | InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) |
| Inchi Key | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/PD-173074.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PD173074-chemical-structure-s1264.gif |