Bardoxolone Methyl
Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.
| Trivial name | RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me |
| Catalog Number | S8078 |
| Molecular Formula | C32H43NO4 |
| CAS# | 218600-53-4 |
| Inchi | InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m 0/s1 |
| Inchi Key | WPTTVJLTNAWYAO-KPOXMGGZSA-N |
| SMILES | CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C |
| Size | 200mg |
| Supplier Page | http://www.selleckchem.com/products/bardoxolone-methyl.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bardoxolone-Methyl-chemical-structure-s8078.gif |