Demethylnobiletin
Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.
| Trivial name | 5-Demethylnobiletin |
| Catalog Number | S9421 |
| Molecular Formula | C20H20O8 |
| CAS# | 2174-59-6 |
| Inchi | InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3 |
| Inchi Key | DOFJNFPSMUCECH-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O)OC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/demethylnobiletin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/demethylnobiletin-chemical-structure-s9421.gif |