AZD5991
AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
| Trivial name | N/A |
| Catalog Number | S8643 |
| Molecular Formula | C35H34ClN5O3S2 |
| CAS# | 2143010-83-5 |
| Inchi | InChI=1S/C35H34ClN5O3S2/c1-20-31-29(38-40(20)3)19-45-17-22-15-23(41(4)37-22)18-46-24-14-21-8-5-6-9-25(21)30(16-24)44-13-7-10-26-27-11-12-28(36)32(31)33(27)39(2)34(26)35(42)43/h5-6,8-9,11-12,14-16H,7,1 0,13,17-19H2,1-4H3,(H,42,43) |
| Inchi Key | KBQCEQAXHPIRTF-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/azd5991.html |
| Additional Information | https://file.selleck.cn/downloads/struct/azd5991-chemical-structure-s8643.gif |