Ensartinib dihydrochloride

Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.

Trivial name X-396 dihydrochloride
Catalog Number S2934
Molecular Formula C11H10N2O2S
CAS# 2137030-98-7
Inchi InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14)
Inchi Key SYENTKHGMVKGAQ-UHFFFAOYSA-N
SMILES C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3
Size 5mg
Supplier Page http://www.selleckchem.com/products/ensartinib-dihydrochloride.html
Additional Information https://file.selleck.cn/downloads/struct/ensartinib-dihydrochloride-chemical-structure-s2934.gif