HS-10296 hydrochloride

HS-10296 hydrochloride(Almonertinib (hydrochloride), HS-10296 HCl) is an irreversible, third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations, T790M resistance mutation. It exhibits inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37 nM, 0.29 nM, and 0.21 nM, respectively. It also exhibits anti-tumor activity.

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Trivial name	Almonertinib (hydrochloride), HS-10296 HCl
Catalog Number	E4886
Molecular Formula	C27H41NO2
CAS#	2134096-03-8
Inchi	InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27- /m0/s1
Inchi Key	QASFUMOKHFSJGL-LAFRSMQTSA-N
SMILES	CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
Size	1g
Supplier Page	http://www.selleckchem.com/products/hs-10296-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E4886-HS-10296-hydrochloride-chemical-structure.png