OPB-171775
OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST).
| Catalog Number | E4695 |
| Molecular Formula | C21H18FN5O |
| CAS# | 2131210-15-4 |
| Inchi | InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) |
| Inchi Key | MPVGZUGXCQEXTM-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/opb-171775.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4695-OPB-171775-chemical-structure.png |