OPB-171775
OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST).
| Catalog Number | E4695 |
| Molecular Formula | C13H16N4O |
| CAS# | 2131210-15-4 |
| Inchi | InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1 |
| Inchi Key | JNAHVYVRKWKWKQ-CYBMUJFWSA-N |
| SMILES | CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/opb-171775.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4695-OPB-171775-chemical-structure.png |