VU661013
VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
| Trivial name | N/A |
| Catalog Number | S8758 |
| Molecular Formula | C39H39Cl2N5O4 |
| CAS# | 2131184-57-9 |
| SMILES | CC1CN(C(=O)C2=C(C3=C(N12)C(=C(C=C3)Cl)C4=C(N(N=C4C)C)C)CCCOC5=CC(=C(C(=C5)C)Cl)C)C6=CN(C7=C6C=C(C=C7)C(=O)O)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/vu661013.html |
| Additional Information | https://file.selleck.cn/downloads/struct/vu661013-chemical-structure-s8758.gif |