STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.IC50 & Target: EC50: 9 μM (K562 cells), 5 μM (KU812 cells)In Vitro: STAT5-IN-2 has EC50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively.
STAT5-IN-2 (100 nM-50 μM; 48 hours) has EC50 values of 2.6 μM and 3.5 μM in KG1a and MV-4-11 cells, respectively.
STAT5-IN-2 (10 μM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells).
STAT5-IN-2 (10 μM; 24 hours) blocks phosphorylation of STAT5.