GW274150
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation.
| Catalog Number | E7778 |
| Molecular Formula | C6H13NO3S |
| CAS# | 210354-22-6 |
| Inchi | InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1 |
| Inchi Key | KINWYTAUPKOPCQ-YFKPBYRVSA-N |
| SMILES | C(CO)CSCC(C(=O)O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gw274150.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7778-gw274150-chemical-structure-tube.png |