LY411575
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells. LY411575 induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S2714 |
| Molecular Formula | C26H23F2N3O4 |
| CAS# | 209984-57-6 |
| Inchi | InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1 |
| Inchi Key | ULSSJYNJIZWPSB-CVRXJBIPSA-N |
| SMILES | CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/ly-411575.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY-411575-chemical-structure-s2714.gif |