Pralsetinib (BLU-667)

Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T).

Price Not Available 10mM/1mL Pralsetinib (BLU-667) Supplier Page

Trivial name	CS 3009, Gavreto
Catalog Number	S8716
Molecular Formula	C27H32FN9O2
CAS#	2097132-94-8
Inchi	InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35 ,36)/t18-,19-,27+/m0/s1
Inchi Key	GBLBJPZSROAGMF-RWYJCYHVSA-N
SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/blu-667.html
Additional Information	https://file.selleck.cn/downloads/struct/blu-667-chemical-structure-s8716.gif