Selitrectinib (LOXO-195)

Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.

Price Not Available 10mM/1mL Selitrectinib (LOXO-195) Supplier Page

Trivial name	BAY 2731954
Catalog Number	S8636
Molecular Formula	C20H21FN6O
CAS#	2097002-61-2
Inchi	InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
Inchi Key	OEBIHOVSAMBXIB-SJKOYZFVSA-N
SMILES	CC1CCC2=C(C=C(C=N2)F)C3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/loxo-195.html
Additional Information	https://file.selleck.cn/downloads/struct/loxo-195-chemical-structure-s8636.gif