Nemtabrutinib (ARQ 531)

Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.

Price Not Available 10mM/1mL Nemtabrutinib (ARQ 531) Supplier Page

Trivial name	MK-1026
Catalog Number	S8711
Molecular Formula	C25H23ClN4O4
CAS#	2095393-15-8
Inchi	InChI=1S/C25H23ClN4O4/c26-21-10-17(34-16-4-2-1-3-5-16)8-9-19(21)23(32)20-11-27-24-22(20)25(29-14-28-24)30-15-6-7-18(12-31)33-13-15/h1-5,8-11,14-15,18,31H,6-7,12-13H2,(H2,27,28,29,30)/t15-,18+/m1/s1
Inchi Key	JSFCZQSJQXFJDS-QAPCUYQASA-N
SMILES	C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/arq531.html
Additional Information	https://file.selleck.cn/downloads/struct/arq-531-chemical-structure-s8711.gif