LYN-1604
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.
| Trivial name | N/A |
| Catalog Number | S8597 |
| Molecular Formula | C33H45Cl4N3O2 |
| CAS# | 2088939-99-3 |
| Inchi | InChI=1S/C33H43Cl2N3O2.2ClH/c1-24(2)19-37(20-25(3)4)22-33(39)38-15-13-36(14-16-38)21-32(30-12-11-29(34)18-31(30)35)40-23-26-9-10-27-7-5-6-8-28(27)17-26;;/h5-12,17-18,24-25,32H,13-16,19-23H2,1-4H3;2*1H |
| Inchi Key | GZCBLOPFZPJUOQ-UHFFFAOYSA-N |
| SMILES | CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(C2=C(C=C(C=C2)Cl)Cl)OCC3=CC4=CC=CC=C4C=C3 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/lyn-1604.html |
| Additional Information | https://file.selleck.cn/downloads/struct/lyn-1604-chemical-structure-s8597.gif |