Uzansertib (INCB053914)
Uzansertib (INCB053914) is a novel, ATP-competitive, small molecule, pan-inhibitor of PIM kinases with IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays.
Trivial name | N/A |
Catalog Number | S8800 |
Molecular Formula | C26H26F3N5O3.H3O4P |
CAS# | 2088852-47-3 |
Inchi | InChI=1S/C26H26F3N5O3.H3O4P/c1-12-10-34(11-17(30)25(12)36)24-13-5-8-20(35)22(13)31-9-19(24)33-26(37)18-7-6-16(29)23(32-18)21-14(27)3-2-4-15(21)28;1-5(2,3)4/h2-4,6-7,9,12,17,20,25,35-36H,5,8,10-11,30H2 ,1H3,(H,33,37);(H3,1,2,3,4)/t12-,17+,20+,25+;/m0./s1 |
Inchi Key | CYYVLFVRZDZABX-SEDYQSMDSA-N |
SMILES | CC1CN(CC(C1O)N)C2=C3CCC(C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O.OP(=O)(O)O |
Size | 1mg |
Supplier Page | http://www.selleckchem.com/products/incb053914.html |
Additional Information | https://file.selleck.cn/downloads/struct/incb053914-chemical-structure-s8800.gif |