DAPT
DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.
| Trivial name | GSI-IX, LY-374973 |
| Catalog Number | S2215 |
| Molecular Formula | C23H21Cl2FN4O3 |
| CAS# | 208255-80-5 |
| Inchi | InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29) |
| Inchi Key | LPFWVDIFUFFKJU-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/DAPT-GSI-IX.html |
| Additional Information | https://file.selleck.cn/downloads/struct/DAPT-GSI-IX-chemical-structure-S2215.gif |