DAPT
DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.
| Trivial name | GSI-IX, LY-374973 |
| Catalog Number | S2215 |
| Molecular Formula | C₂₃H₂₆F₂N₂O₄ |
| CAS# | 208255-80-5 |
| Inchi | InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
| Inchi Key | DWJXYEABWRJFSP-XOBRGWDASA-N |
| SMILES | CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/DAPT-GSI-IX.html |
| Additional Information | https://file.selleck.cn/downloads/struct/DAPT-GSI-IX-chemical-structure-S2215.gif |