Inavolisib (GDC-0077)
Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
| Trivial name | RG6114, RO-7113755 |
| Catalog Number | S8668 |
| Molecular Formula | C18H19F2N5O4 |
| CAS# | 2060571-02-8 |
| SMILES | CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/gdc-0077.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gdc-0077-chemical-structure.gif |