THZ-P1-2| ChemScene
THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines.In Vitro: THZ-P1-2 (0.2-11.4 μM) exhibits approximately 75% inhibition of PI-4,5-P2 formation by PI5P4Kα and PI5P4Kγ and 50% inhibition by PI5P4Kβ at a concentration of 0.7 μM.
THZ-P1-2 (10-100000 nM; 72 hours) shows modest anti-proliferative activity in all six AML/ALL cell lines with IC50 values in the low micromolar range.
Trivial name | THZ-P1-2 |
Catalog Number | CS-0128545 |
Molecular Formula | 531.61 |
CAS# | 2058075-45-7 |
Purity | >98% |
Condensed Formula | C31H29N7O2 |
Size | 5mg |
Supplier Page | www.chemscene.com/2058075-45-7.html |