GNF4877
GNF4877 is an aminopyrazine and a potent inhibitor of GSK3β and DYRK1A with an IC50 of 16 nM and 6 nM, respectively. It blocks nuclear factor of activated T-cells (NFATc) nuclear export, promotes β-cell proliferation, and is useful for research on diabetes drug development.
| Catalog Number | E7732 |
| Molecular Formula | C22H22N2O4 |
| CAS# | 2041073-22-5 |
| Inchi | InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1 |
| Inchi Key | OUJTZYPIHDYQMC-LJQANCHMSA-N |
| SMILES | CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/gnf4877.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7732-GNF4877-chemical-structure.png |