Pexidartinib Hydrochloride

Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R). It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice. It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling.

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Trivial name	PLX-3397 hydrochloride
Catalog Number	E6007
Molecular Formula	C40H50N8O6
CAS#	2040295-03-0
Inchi	InChI=1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,2 1-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1
Inchi Key	FKRSSPOQAMALKA-CUPIEXAXSA-N
SMILES	CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC
Size	1g
Supplier Page	http://www.selleckchem.com/products/pexidartinib-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E6007-Pexidartinib-hydrochloride-chemical-structure.png