Brefeldin A (BFA)
Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
| Trivial name | Cyanein, Decumbin |
| Catalog Number | S7046 |
| Molecular Formula | C16H24O4 |
| CAS# | 20350-15-6 |
| Inchi | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1 |
| Inchi Key | KQNZDYYTLMIZCT-KQPMLPITSA-N |
| SMILES | CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/brefeldin-a.html |
| Additional Information | https://file.selleck.cn/downloads/struct/brefeldin-A-chemical-structure-s7046.gif |