Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.In Vitro: Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversedby LY294002).
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis.
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG.
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway.
In Vivo: Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].