JIB-04
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.
| Trivial name | NSC 693627 |
| Catalog Number | S7281 |
| Molecular Formula | C17H13ClN4 |
| CAS# | 199596-05-9 |
| Inchi | InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+ |
| Inchi Key | YHHFKWKMXWRVTJ-OQKWZONESA-N |
| SMILES | C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/jib-04.html |
| Additional Information | https://file.selleck.cn/downloads/struct/JIB04-chemical-structure-s7281.gif |