YKL-5-124
YKL-5-124 is a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for inhibiting CDK7/Mat1/CycH, CDK2 and CDK9 respectively. It displays biochemical and cellular selectivity for CDK7 over CDK12/13.
| Trivial name | N/A |
| Catalog Number | S8863 |
| Molecular Formula | C28H33N7O3 |
| CAS# | 1957203-01-8 |
| Inchi | InChI=1S/C28H33N7O3/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37)/t 22-/m1/s1 |
| Inchi Key | KPABJHHKKJIDGX-JOCHJYFZSA-N |
| SMILES | CC1(C2=C(CN1C(=O)NC(CN(C)C)C3=CC=CC=C3)C(=NN2)NC(=O)C4=CC=C(C=C4)NC(=O)C=C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ykl5-124.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ykl-5-124-chemical-structure-s8863.gif |