KN-93 hydrochloride

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

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Catalog Number	E5833
Molecular Formula	C22H29FO5
CAS#	1956426-56-4
Inchi	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Inchi Key	UREBDLICKHMUKA-CXSFZGCWSA-N
SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/kn-93-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E5833-KN-93-hydrochloride-chemical-structure.png