Temuterkib (LY3214996)
Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.
Trivial name | N/A |
Catalog Number | S8534 |
Molecular Formula | C22H27N7O2S |
CAS# | 1951483-29-6 |
Inchi | InChI=1S/C22H27N7O2S/c1-22(2)19-15(20(30)29(22)9-8-28-10-12-31-13-11-28)14-17(32-19)16-4-6-23-21(25-16)26-18-5-7-24-27(18)3/h4-7,14H,8-13H2,1-3H3,(H,23,25,26) |
Inchi Key | JNPRPMBJODOFEC-UHFFFAOYSA-N |
SMILES | CC1(C2=C(C=C(S2)C3=NC(=NC=C3)NC4=CC=NN4C)C(=O)N1CCN5CCOCC5)C |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/ly3214996.html |
Additional Information | https://file.selleck.cn/downloads/struct/ly3214996-chemical-structure-s8534.gif |