dBET6
dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis.
| Trivial name | N/A |
| Catalog Number | S8762 |
| Molecular Formula | C42H45ClN8O7S |
| CAS# | 1950634-92-0 |
| Inchi | InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52 )47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1 |
| Inchi Key | JGQPZPLJOBHHBK-UFXYQILXSA-N |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/dbet6.html |
| Additional Information | https://file.selleck.cn/downloads/struct/dbet6-chemical-structure-s8762.gif |