Semaxanib (SU5416)
Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.Semaxanib (SU5416) can be used to induce animal models of chronic intermittent hypoxia.
| Trivial name | semaxinib |
| Catalog Number | S2845 |
| Molecular Formula | C25H28ClNO2 |
| CAS# | 204005-46-9 |
| Inchi | InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24-; |
| Inchi Key | RPFIMPDXTABYCN-BJFQDICYSA-N |
| SMILES | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/semaxanib-su5416.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Semaxanib-chemical-structure-s2845.gif |
