Cardamonin can supress numerous signaling pathways including TNF-α, COX-2, Wnt/β-catenin and NF-κB, suppresses melanogenesis by inhibition of Wnt/β-catenin signaling, and possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation. It is a natural product isolated and purified from the seeds of Alpinia katsumadai Hayata.