Tipifarnib
Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
| Trivial name | R115777, IND 58359 |
| Catalog Number | S1453 |
| Molecular Formula | C27H22Cl2N4O |
| CAS# | 192185-72-1 |
| Inchi | InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1 |
| Inchi Key | PLHJCIYEEKOWNM-HHHXNRCGSA-N |
| SMILES | CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Tipifarnib(R115777).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Tipifarnib-Zarnestra-chemical-structure-S1453.gif |