Lenalidomide
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
| Trivial name | CC-5013 |
| Catalog Number | S1029 |
| Molecular Formula | C13H13N3O3 |
| CAS# | 191732-72-6 |
| Inchi | InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
| Inchi Key | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N |
| Size | 500mg |
| Supplier Page | http://www.selleckchem.com/products/lenalidomide-s1029.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Lenalidomide-chemical-structure-S1029.gif |