Lenalidomide
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
| Trivial name | CC-5013 |
| Catalog Number | S1029 |
| Molecular Formula | C10H7NO2 |
| CAS# | 191732-72-6 |
| Inchi | InChI=1S/C10H7NO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H,12,13) |
| Inchi Key | VQMSRUREDGBWKT-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CC=N2)C(=O)O |
| Size | 500mg |
| Supplier Page | http://www.selleckchem.com/products/lenalidomide-s1029.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Lenalidomide-chemical-structure-S1029.gif |