Pomalidomide
Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
| Trivial name | CC-4047 |
| Catalog Number | S1567 |
| Molecular Formula | C13H11N3O4 |
| CAS# | 19171-19-8 |
| Inchi | InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) |
| Inchi Key | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/Pomalidomide(CC-4047).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Pomalidomide-chemical-structure-S1567.gif |