Lazertinib
Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.
| Trivial name | YH25448,GNS-1480 |
| Catalog Number | S8724 |
| Molecular Formula | C30H34N8O3 |
| CAS# | 1903008-80-9 |
| Inchi | InChI=1S/C30H34N8O3/c1-5-28(39)32-23-17-24(26(40-4)18-25(23)37-13-15-41-16-14-37)33-30-31-12-11-27(34-30)38-20-22(19-36(2)3)29(35-38)21-9-7-6-8-10-21/h5-12,17-18,20H,1,13-16,19H2,2-4H3,(H,32,39)(H,31, 33,34) |
| Inchi Key | RRMJMHOQSALEJJ-UHFFFAOYSA-N |
| SMILES | CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/lazertinib-yh25448-gns-1480.html |
| Additional Information | https://file.selleck.cn/downloads/struct/lazertinib-yh25448-gns-1480-chemical-structure-s8724.gif |