LY 3200882
LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.
| Trivial name | N/A |
| Catalog Number | S8772 |
| Molecular Formula | C24H29N5O3 |
| CAS# | 1898283-02-7 |
| Inchi | InChI=1S/C24H29N5O3/c1-24(2,30)21-13-17(5-9-25-21)27-22-14-19(6-10-26-22)32-20-15-29(18-3-4-18)28-23(20)16-7-11-31-12-8-16/h5-6,9-10,13-16,18,30H,3-4,7-8,11-12H2,1-2H3,(H,25,26,27) |
| Inchi Key | PNPFMWIDAKQFPY-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=NC=CC(=C1)NC2=NC=CC(=C2)OC3=CN(N=C3C4CCOCC4)C5CC5)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ly3200882.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ly-3200882-chemical-structure-s8772.gif |