TBK1/IKKε-IN-5
TBK1/IKKε-IN-5 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.
| Trivial name | compound 1 |
| Catalog Number | S8922 |
| Molecular Formula | C28H31N7O3 |
| CAS# | 1893397-65-3 |
| SMILES | C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=N3)NC4=CC=C(C=C4)N5CCN(CC5)C6COC6)C#N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/tbk1-IKKe-in-1-compound1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TBK1-IKKe-IN-1-compound1-chemical-structure-s8922.gif |