A-485
A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.
| Trivial name | N/A |
| Catalog Number | S8740 |
| Molecular Formula | C25H24F4N4O5 |
| CAS# | 1889279-16-6 |
| Inchi | InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1 |
| Inchi Key | VRVJKILQRBSEAG-LFPIHBKWSA-N |
| SMILES | CC(C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)C3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/a-485.html |
| Additional Information | https://file.selleck.cn/downloads/struct/a-485-chemical-structure-s8740.gif |