Brepocitinib (PF-06700841)
Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
| Trivial name | PF-841 |
| Catalog Number | S8804 |
| Molecular Formula | C18H21F2N7O |
| CAS# | 1883299-62-4 |
| Inchi | InChI=1S/C18H21F2N7O/c1-25-8-11(7-22-25)23-17-21-5-4-15(24-17)26-9-12-2-3-13(10-26)27(12)16(28)14-6-18(14,19)20/h4-5,7-8,12-14H,2-3,6,9-10H2,1H3,(H,21,23,24)/t12?,13?,14-/m0/s1 |
| Inchi Key | BUWBRTXGQRBBHG-RUXDESIVSA-N |
| SMILES | CN1C=C(C=N1)NC2=NC=CC(=N2)N3CC4CCC(C3)N4C(=O)C5CC5(F)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/pf-06700841.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-06700841-chemical-structure-s8804.gif |