AZD5153 6-hydroxy-2-naphthoic acid
AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
| Trivial name | AZD5153 HNT salt |
| Catalog Number | S8344 |
| CAS# | 1869912-40-2 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/azd5153-6-hydroxy-2-naphthoic-acid.html |
| Additional Information | https://file.selleck.cn/downloads/struct/azd5153-chemical-structure-S8344.gif |