MI-503
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
| Trivial name | N/A |
| Catalog Number | S7817 |
| Molecular Formula | C28H27F3N8S |
| CAS# | 1857417-13-0 |
| Inchi | InChI=1S/C28H27F3N8S/c1-17-19(2-3-25-23(17)8-21(11-32)39(25)14-18-12-35-36-13-18)15-38-6-4-20(5-7-38)37-26-24-9-22(10-28(29,30)31)40-27(24)34-16-33-26/h2-3,8-9,12-13,16,20H,4-7,10,14-15H2,1H3,(H,35,36 )(H,33,34,37) |
| Inchi Key | DETOMBLLEOZTMZ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC2=C1C=C(N2CC3=CNN=C3)C#N)CN4CCC(CC4)NC5=C6C=C(SC6=NC=N5)CC(F)(F)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/mi-503.html |
| Additional Information | https://file.selleck.cn/downloads/struct/mi-503-chemical-structure-S7817.gif |