3PO
3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
| Trivial name | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
| Catalog Number | S7639 |
| Molecular Formula | C13H10N2O |
| CAS# | 18550-98-6 |
| Inchi | InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+ |
| Inchi Key | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
| SMILES | C1=CC(=CN=C1)C=CC(=O)C2=CC=NC=C2 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/3po.html |
| Additional Information | https://file.selleck.cn/downloads/struct/3po-chemical-structure-s7639.gif |