iJak-381 | MedChemExpress (MCE)
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR)[1].
| Trivial name | iJak-381 |
| Catalog Number | HY-125019 |
| Research Area | Inflammation/Immunology |
| CAS# | 1831144-46-7 |
| Purity | ≥98.0% |
| SMILES | O=C(C1=C2N=CC=CN2N=C1)NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C5=CC(Cl)=CC=C5OC(F)F |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/ijak-381.html |