β-Sheet Breaker Peptide iAβ5 | MedChemExpress (MCE)
β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, β-Sheet Breaker Peptide iAβ5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions[1][2][3].
| Trivial name | β-Sheet Breaker Peptide iAβ5 |
| Catalog Number | HY-P1047 |
| Alternative Name(s) | [Pro18, Asp21] β-Amyloid (17-21) |
| Research Area | Neurological Disease |
| CAS# | 182912-74-9 |
| Purity | 99.92% |
| SMILES | OC(C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@@H](N)CC(C)C)=O)=O)=O)=O)=O |
| PubChem Chemical Structure ID | 10146049 |
| Size | 10 mg |
| Supplier Page | https://www.medchemexpress.com/β-sheet-breaker-peptide-iaβ5.html |