ZD8321

ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) (Ki= 13±1.7 nM), suppressing adhesion of neutrophils to TNFa-activated endothelial cells. That of cancer cells with high intracellular elastase activity was also suppressed by ZD8321.

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Catalog Number	182073-77-4
Alternative Name(s)	methyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate; 1-(2-methoxycarbonyl-3-methylbutyryl)-N-(2-methyl-1-(trifluoroacetyl)propyl)pyrrolidine-2-carboxamide; ZD 8321; ZD-8321
Molecular Formula	C16H11N3O
CAS#	182073-77-4
Inchi	1S/C18H28F3N3O5/c1-9(2)12(14(25)18(19,20)21)22-15(26)11-7-6-8-24(11)16(27)13(10(3)4)23-17(28)29-5/h9-13H,6-8H2,1-5H3,(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
Inchi Key	ZYLBZJKJNAYAFU-AVGNSLFASA-N
Size	Please inquire
Supplier Page	https://www.bocsci.com/zd8321-cas-182073-77-4-item-7586.html