BAY 1436032
BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants.
| Trivial name | N/A |
| Catalog Number | S8530 |
| Molecular Formula | C26H30F3N3O3 |
| CAS# | 1803274-65-8 |
| Inchi | InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)/t16-,19+/m 0/s1 |
| Inchi Key | RNMAUIMMNAHKQR-QFBILLFUSA-N |
| SMILES | CC1CC(CC(C1)(C)C)N2C3=C(C=C(C=C3)CCC(=O)O)N=C2NC4=CC=C(C=C4)OC(F)(F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/bay-1436032.html |
| Additional Information | https://file.selleck.cn/downloads/struct/bay-1436032-chemical-structure-s8530.gif |